ISCOM or ISCOM-matrix comprising a mucous targetting substance and an antigen

A method of eliciting an immune response in a subject, comprising administering to a mucosal organ of a subject an effective amount of an immunogenic composition for eliciting an immune response comprising at least one passenger immunogen and an immunostimulating complex, said immunostimulating complex being formed from at least one saponin and at least one lipid, said composition further comprising at least one mucosal surface targeting agent, said targeting agent being a protein, protein derivative or carbohydrate, said targeting agent being a substance that targets lymphatic tissue and induces an immune response when administered locally on mucous membrane;

• and wherein administration of said composition to said mucosal organ elicits an immune response not only at said mucosal organ, but also at a further mucosal organ remote from said mucosal organ to which said composition is administered.