Chlamydia antigens and corresponding DNA fragments and uses thereof
AssigneeAventis Pasteur Limited/Aventis Pasteur Limitee
InventorsAndrew D. Murdin, Raymond P. Oomen, Pamela L. Dunn
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Abstract
In summary of this disclosure, the present invention provides a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. pneumoniae, employing a vector, containing a nucleotide sequence encoding an POMP91B precursor protein of a strain of Chlamydia pneumoniae and a promoter to effect expression of the POMP91B precursor gene in the host. Modifications are possible within the scope of this invention.
Claims5
An isolated polypeptide comprising a polypeptide from a strain of Chlamydia selected from the group consisting of:
- (a) a polypeptide comprising the amino acid sequence SEQ ID NO:2;
- and
- (b) a polypeptide that is at least 90% homologous to SEQ ID NO:2;
- wherein said isolated polypeptide, when administered in an immunogenically-effective amount to a mammal, induces a mucosal immune response by said mammal against Chlamydia pneumoniae.
Dependencies are inferred from the claim text.