Human tumor necrosis factor receptor TR10
AssigneeHuman Genome Sciences, Inc.
InventorsJian Ni, Craig A. Rosen
Life of this patent
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Abstract
The present invention relates to a novel protein, TR10, which is a member of the tumor necrosis factor (TNF) receptor superfamily and the TRAIL receptor subfamily. In particular, isolated nucleic acid molecules are provided encoding the human TR10 protein. TR10 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR10 activity.
Claims64
An isolated protein comprising an amino acid sequence selected from the group consisting of:
- (a) amino acid residues −55 to 331 of SEQ ID NO:2;
- (b) amino acid residues −54 to 331 of SEQ ID NO:2;
- and
- (c) amino acid residues 1 to 331 of SEQ ID NO:2.
An isolated protein comprising an amino acid sequence selected from the group consisting of:
- (a) amino acid residues 1 to 157 of SEQ ID NO:2;
- and
- (b) amino acid residues 1 to 175 of SEQ ID NO:2;
- wherein said protein is capable of binding TRAIL.
An isolated protein comprising an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC Deposit No. 209040;
- (b) the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC Deposit No. 209040, excluding the N-terminal methionine residue;
- and
- (c) the amino acid sequence of the mature polypeptide encoded by the cDNA contained in ATCC Deposit No. 209040.
An isolated protein comprising the amino acid sequence of the extracellular domain of the polypeptide encoded by the cDNA contained in ATCC Deposit No. 209040, wherein said protein is capable of binding TRAIL.
An isolated protein comprising a first amino acid sequence 90% or more identical to a second amino acid sequence selected from the group consisting of:
- (a) amino acid residues −55 to 331 of SEQ ID NO:2;
- (b) amino acid residues −54 to 331 of SEQ ID NO:2;
- (c) amino acid residues 1 to 331 of SEQ ID NO:2;
- (d) amino acid residues 1 to 157 of SEQ ID NO:2;
- and
- (e) amino acid residues 1 to 175 of SEQ ID NO:2;
- wherein said protein is capable of binding TRAIL.
An isolated protein comprising a first amino acid sequence 90% or more identical to a second amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC Deposit No. 209040;
- (b) the amino acid sequence of the full-length polypeptide encoded by the cDNA contained in ATCC Deposit No. 209040, excluding the amino-terminal methionine;
- (c) the amino acid sequence of the mature polypeptide encoded by the cDNA contained in ATCC Deposit No. 209040;
- and
- (d) the amino acid sequence of the extracellular domain of the polypeptide encoded by the cDNA contained in ATCC Deposit No. 209040;
- wherein said protein is capable of binding TRAIL.
An isolated protein comprising a fragment of the amino acid sequence of SEQ ID NO:2, wherein said protein is capable of binding TRAIL.
An isolated protein consisting of at least 30 contiguous amino acid residues of SEQ ID NO:2, wherein said protein further comprises a heterologous amino acid sequence.
Dependencies are inferred from the claim text.