Conjugate vaccine for nontypeable Haemophilus influenzae
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsXin-Xing Gu, Chao-Ming Tsai, David J. Lim, John B. Robbins
Life of this patent
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Abstract
A conjugate vaccine for Nontypeable Haemophilus influenzae comprising lipooligosaccharide from which esterified fatty acids have been removed conjugated to an immunogenic carrier. The vaccine is useful for prevention of otitis media and respiratory infections in mammals.
Claims19
A method of inducing a protective immune response against nontypeable Haemophilus influenzae (NTHi) in a mammal comprising the step of administering to said mammal an effective immunoprotective amount of a conjugate vaccine comprising lipooligosaccharide (LOS) from which esterified fatty acids have been removed from lipid A to form detoxified LOS (dLOS) and an immunogenic carrier covalently linked thereto.
Dependencies are inferred from the claim text.