Melanotropin analogs for potential radiopharmaceuticals for diagnosis and treatment of melonoma
AssigneeThe Curators of the University of Missouri
InventorsSilvia S. Jurisson, Thomas P. Quinn, Michael F. Giblin
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Abstract
A compound for use as a diagnostic or therapeutic pharmaceutical and method of using the same where the compound consists essentially of an alpha-melanotropin stimulating hormone analog which has integrally located a radionuclide. The radionuclide is administered to the body in an amount sufficient to allow uptake and retention by the tumor cells.
Claims16
A compound for use as a diagnostic or therapeutic pharmaceutical, said compound consisting essentially of:
- a stable cyclic alpha-melanotropin stimulating hormone;
- a radionuclide integral to said alpha-melanotropin stimulating hormone;
- and
- a chelating compound bound to said pharmaceutical.
A method of using an alpha-melanotropin stimulating hormone including steps of:
- complexing a stable cyclic alpha-melanotropin peptide with an integral radionuclide from the group consisting essentially of 99mTc, 188Re, and nonradioactive Re, and a chelating compound;
- and
- administering to the body an amount of the complex of the alpha-melanotropin peptide complexed with the integral radionuclide to allow uptake and retention by the tumor cells.
A compound for use as a diagnostic or therapeutic pharmaceutical for targeting any receptor, said compound consisting essentially of:
- at least one alpha melanotropin stimulating hormone peptide integrally cyclized by coordination between two adjacent cysteines and at least one from the group consisting essentially of a non-contiguous cysteine, amide or amine, having a formula of
- or
- where X=any amino acid, n=1 to 1000, Z=a chelating compound, and E=radioelement which binds with at least two of the Cys-SH groups in said formula.
A compound for use as a diagnostic or therapeutic pharmaceutical, said compound consisting essentially of:
- an alpha-melanotropin stimulating hormone;
- a radionuclide integral to said alpha-melanotropin stimulating hormone, wherein amino acid substitutions in said alpha-melanotropin stimulating hormone facilitate radiolabeling.
Dependencies are inferred from the claim text.