Silver-containing compositions, devices and methods for making
AssigneeAcrymed
InventorsBruce L. Gibbins, Lance D. Hopman
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Abstract
The present invention comprises methods and compositions for making a silver-containing antimicrobial hydrophilic material. More particularly, the present invention comprises methods and compositions for stabilized silver antimicrobial devices comprising a matrix comprising a polymer network and a non-gellable polysaccharide, and an active agent. The matrix may be formed into any desired shape for its desired uses.
Claims25
A method of making a matrix, comprising:
- (a) combining a hydrophilic polymer, a cross-linking agent, non-gellable polysaccharide
- (b) adding in no particular order, a solution of a cation-donating compound, wherein the cations are metal ions, and a solution of an anion-donating compound, wherein the anions are added in excess of the metal cations;
- and which react to form a metal colloid;
- (c) adding a cross-linking catalyst and N,N,N′N′-tetramethylethylene diamine and mixing;
- (d) forming the mixture into a desired shape;
- and where the metal colloid is directly incorporated in the matrix without the prior incorporation of the metal colloid into another delivery vehicle.
A method for making a hydrophillic matrix having antimicrobial activity, comprising,
- directly incorporating a metal colloid in a hydrophillic matrix by forming a metal colloid by adding to the hydrophilic matrix, in no particular order, an organic solvent solution of a cation-donating compound, wherein the cations are metal ions, and an organic solvent solution of an anion-donating compound, wherein the anions are added in excess of the metal cations;
- such that the association of the metal cation and the anion of the anion-donating compound is favored.
A biocompatible hydrophilic polymeric antimicrobial matrix, comprising a hydrophilic cross-linked polymer network, and a metal colloid directly incorporated in the matrix, wherein the metal colloid is formed by the reaction of an anionic solution and a metal cationic solution, and wherein the anions of the anionic solution are in an excess concentration of the metal cations, such that association of the metal cation and the anion is favored.
Dependencies are inferred from the claim text.