Benzanilides as potassium channel openers

A compound having the formula:

• wherein,
• Ar1 is a member selected from the group consisting of indolyl, substituted indolyl, benzofuranyl, substituted benzofuranyl, furanyl, substituted furanyl, thienyl, substituted thienyl, isothiazolyl, substituted isothiazolyl, pyrazolyl, and substituted pyrazolyl;
• X is a member selected from the group consisting of O, S and N—R1,
• wherein, R1 is a member selected from the group consisting of H, (C1-C8)alkyl, substituted , (C1-C8)alkyl, heteroalkyl, substituted heteroalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryl(C1-C4)alkyl, substituted aryl((C1-C4)alkyl, CN, —C(O)R2, —OR3, —C(O)NR3R4, and —S(O)2NR3R4;
• wherein, R2 is a member selected from the group consisting of (C1-C8)alkyl, substituted (C1-C8)alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, heterocyclyl, substituted heterocyclyl, alkaryl, substituted aryl, heteroaryl, substituted heteroaryl, aryl(C1-C4)alkyl and substituted aryl(C1-C4)alkyl;
• R3 and R4 are each members independently selected from the group consisting of hydrogen, (C1-C8)alkyl, substituted (C1-C8)alkyl, cycloalkyl, substituted cycloalkyl, heteroalkyl, substituted heteroalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, aryl((C1-C4)alkyl and substituted aryl(C1-C4)alkyl, or R3 and R4 can be combined with the nitrogen to which each is attached to form a 5-, 6- or 7-membered ring optionally having additional heteroatoms at the ring vertices;
• and
• Y is a member selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 substituted alkyl, —OCH3 and —OCF3.