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US 6,605,720 B1Granted
Process for making spirolactone compounds
AssigneesMerck & Co., Inc., Banyu Pharmaceutical Co., Ltd.
InventorsKenji Maeda, Shinji Kato, Takehiko Iida, David M. Tschaen
Life of this patent
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Abstract
This invention relates to processes for making spirolactone compounds analogous to formula I:
Claims13
A process for preparing a compound of formula I:
- comprising the steps of:
- a. Combining a strong base with phenyl isonicotinamide in an aprotic solvent;
- b. Adding a protected ketone;
- c. Adjusting the pH with an acid to between 1 and 4 to deprotect the ketone;
- d. Treating the ketone with a reducing agent to provide an alcohol;
- e. Activating the alcohol to make a leaving group;
- f. Displacing the leaving group with a cyanide to produce a nitrile;
- g. Hydrolyzing the nitrile with aqueous acid to produce the compound of formula I.
5 more elements
Dependencies are inferred from the claim text.