Gene whose expression promotes differentiation of myeloid progenitor cells into neutrophils and/or monocytes/macrophages
AssigneeBoard of Trustees of Michigan State University
InventorsRichard C. Schwartz, Qiang Tian
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Abstract
The present invention provides a human gene sequence that encodes the CDDP-1 polypeptide, which is involved in cell differentiation, in particular differentiation of undifferentiated progenitor cells into neutrophils, monocytes/macrophages, mast cells, and/or erythroid cells. Assays for detecting CDDP-1 expression, vectors that express CDDP-1, methods for using CDDP-1 to induce or promote cell differentiation, and transgenic animals deficient in one or both CDDP-1 alleles are described.
Claims11
An isolated cDNA molecule that encodes a human C/EBP Differential Display Product-1 (CDDP-1), wherein the CDDP-1 consists essentially of the amino acid sequence set forth in SEQ ID NO:2.
An isolated cDNA molecule that encodes human C/EBP Differential Display Product-1 (CDDP-1), wherein the CDDP-1 consists essentially of the amino acid sequence set forth in SEQ ID NO:2 and the CDDP-1 promotes differentiation of murine promyelocytes (MPRO cells) along a neutrophilic, monocytic, or macrophage differentiation pathway.
An isolated human cDNA encoding CDDP-1 which consists essentially of the nucleotide sequence set forth in SEQ ID NO:1.
A vector comprising a nucleic acid molecule that encodes human C/EBP Differential Display Product-1 (CDDP-1) operably linked to a heterologous promoter wherein the CDDP-1 consists essentially of the amino acid sequence set forth in SEQ ID NO:2 and the CDDP-1 promotes differentiation of murine promyelocytes (MPRO cells) along a neutrophilic, monocytic, or macrophage differentiation pathway.
A vector comprising a nucleic acid molecule that encodes human C/EBP Differential Display Product-1 (CDDP-1) which consists essentially of the amino acid sequence set forth in SEQ ID NO:2, and that is operably linked to a heterologous promoter.
A vector containing a nucleic acid consisting essentially of the nucleotide sequence set forth in SEQ ID NO:1 and wherein the DNA is operably linked to a heterologous promoter.
A cell line harboring a vector containing a nucleic acid consisting essentially of the nucleotide sequences set forth in SEQ ID NO:1 and wherein the nucleic acid is operably linked to a heterologous promoter.
Dependencies are inferred from the claim text.