Prostaglandin D synthase-specific monoclonal antibody
AssigneesMaruha Corporation, Osaka Bioscience Institute
InventorsHiroshi Oda, Nobuyuki Sato, Masazumi Nishikawa, Kosuke Seiki, Yoshihiro Urade, Fumitaka Saji
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Abstract
The invention relates to a monoclonal antibody specifically recognizing lipocalin-type prostaglandin D synthase (L-PGDS), a hybridoma producing the monoclonal antibody, methods for detection of L-PGDS or diseases by the monoclonal antibody, and a kit for detection of L-PGDS by the monoclonal antibody. According to the invention, there is provided a monoclonal antibody specific to L-PGDS.
Claims11
A monoclonal antibody produced by hybridoma 7F5 or 10A3, deposited as FERM BP-5711 and FERM BP-5713, respectively, wherein the monoclonal antibody specifically recognizes human L-PGDS.
A monoclonal antibody produced by hybridoma 9A6, deposited as FERM BP-5712, wherein the monoclonal antibody specifically recognizes human L-PGDS.
A monoclonal antibody produced by hybridoma 6F5, deposited as FERM BP-5710, wherein the monoclonal antibody specifically recognizes human L-PGDS.
A monoclonal antibody produced by hybridoma 1B7, deposited as FERM BP-5709, wherein the monoclonal antibody specifically recognizes human L-PGDS.
A hybridoma selected from the group consisting of 7F5 or 10A3, deposited as FERM BP-5711 and FERM BP-5713, respectively.
The hybridoma 9A6, deposited as FERM BP-5712.
The hybridoma 6F5, deposited as FERM BP-5710.
The hybridoma 1B7, deposited as FERM BP-5709.
A kit comprising one or two monoclonal antibodies that specifically recognize human L-PGDS, wherein the monoclonal antibodies are selected from the group consisting of:
- (a) a monoclonal antibody produced by hybridoma 7F5 or 10A3, deposited as FERM BP-5711 and FERM BP-5713, respectively;
- (b) a monoclonal antibody produced by hybridoma 9A6, deposited as FERM BP-5712;
- (c) a monoclonal antibody produced by hybridoma 6F5, deposited as FERM BP-5710;
- and
- (d) a monoclonal antibody produced by hybridoma 1B7, deposited as FERM BP-5709,
- wherein at least one of the monoclonal antibodies is labeled with an enzyme or is biotinylated.
A method of detecting L-PGDS, the method comprising contacting the L-PGDS with one or two monoclonal antibodies that specifically recognize human L-PGDS, wherein the monoclonal antibodies are selected from the group consisting of:
- (a) a monoclonal antibody produced by hybridoma 7F5 or 10A3, deposited as FERM BP-5711 and FERM BP-5713, respectively;
- (b) a monoclonal antibody produced by hybridoma 9A6, deposited as FERM BP-5712;
- (c) a monoclonal antibody specifically recognizing human L-PGDS produced by hybridoma 6F5, deposited as FERM BP-5710;
- and
- (d) a monoclonal antibody specifically recognizing human L-PGDS produced by hybridoma 1B7, deposited as FERM BP-5709,
- wherein at least one of the monoclonal antibodies is labeled with an enzyme or is biotinylated.
Dependencies are inferred from the claim text.