Antioxidant enriched adhesive compositions and storage containers therefor
AssigneeClosure Medical Corporation
InventorsIbraheem T. Badejo, Jaime Ayarza, Anthony Voiers, Roy F. Thompson, Jr., Gabriel N. Szabo, Robert V. Toni, William S. C. Nicholson
Life of this patent
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Abstract
An adhesive composition includes a polymerizable adhesive monomer and at least one antioxidant stabilizer, and/or a container for storing said monomer composition that includes an antioxidant stabilizer. The antioxidant stabilizer provides superior stabilization and shelf-life of the composition and/or the container, and may enhance wound healing properties of the monomer composition.
Claims76
An adhesive composition comprising:
- a polymerizable 1,1-disubstituted ethylene monomer;
- and
- an antioxidant stabilizer selected from the group consisting of vitamin E and derivatives thereof in an amount of at least 0.1 percent by weight based on the monomer, vitamin K and derivatives thereof in an amount of at least 0.1 percent by weight based on the monomer, vitamin C and derivatives thereof in an amount of at least 0.1 percent by weight based on the monomer, pentamethyl chromanol, non-phenolic antioxidants, and pentamethylbenzofuranol.
A sterilized adhesive composition comprising:
- a polymerizable 1,1-disubstituted ethylene monomer;
- and
- an antioxidant stabilizer selected from the group consisting of vitamin E and derivatives thereof, vitamin K and derivatives thereof, vitamin C and derivatives thereof, pentamethyl chromanol, non-phenolic antioxidants, octyl gallate, and pentamethylbenzofuranol,
- wherein the adhesive composition has a Sterility Assurance Level of at least 10−3.
A method of making a sterile polymerizable 1,1-disubstituted monomer adhesive composition comprising:
- dispensing a polymerizable 1,1-disubstituted monomer adhesive composition into a container;
- sealing said container;
- and
- sterilizing the composition in the container to a Sterility Assurance Level of at least 10−3,
- wherein said polymerizable 1,1-disubstituted monomer composition comprises:
- at least one polymerizable 1,1-disubstituted ethylene monomer;
- and
- an antioxidant stabilizer selected from the group consisting of vitamin E and derivatives thereof, vitamin K and derivatives thereof, vitamin C and derivatives thereof, pentamethyl chromanol, non-phenolic antioxidants, and pentamethylbenzofuranol.
A method of making an adhesive composition comprising:
- combining at least one polymerizable 1,1-disubstituted ethylene monomer, at least one antioxidant stabilizer, and at least one non-antioxidant medicament,
- wherein said at least one antioxidant stabilizer is selected from the group consisting of vitamin E and derivatives thereof, vitamin K and derivatives thereof, vitamin C and derivatives thereof, pentamethyl chromanol, non-phenolic antioxidants, and pentamethylbenzofuranol.
Dependencies are inferred from the claim text.