Linear polyamine compounds and polyamine-based anti-tumor agents
AssigneeRiken
InventorMasaaki Iwata
Life of this patent
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Abstract
Nobel polyamine compounds and polyamine compounds having carcinostatic action are provided. There are also provided anticancer agents containing as active ingredient at least one of polyamine compounds represented by the following Formula (I) or (III) and/or pharmaceutically acceptable salts thereof. Specifically, there are provided anticancer agents containing as active ingredient at least one of 1,18-bis(ethylamino)-5,14-diazaoctadecane, 1,16-bis(cyclopropylmethylamino)-5,12-diazahexadecane, 1,17-bis(cyclopropylmethylamino)-5,13-diazaheptadecane and/or pharmaceutically acceptable salts thereof.
Claims11
An anticancer agent, which contains, as an active ingredient, 1,15-di(cyclopropylmethylamino)-8-benzyl-4,8,12-triazapentadecane and/or pharmaceutically acceptable salt thereof.
An anti-cancer agent, which contains, as an active ingredient, 1,17-di(cyclopropylmethylamino)-9-benzyl-5,9,13-triazaheptadecane and/or pharmaceuitcally acceptable salt thereof.
A compound or pharmaceutically acceptable salt thereof wherein said compound is 1,15-di(cyclopropylmethylamino)-8-benzyl-4,8,12-triazapentadecane.
A compound or pharmaceutically acceptable salt thereof, wherein said compound is 1,17-di(cyclopropylmethylamino)-9-benzyl-5,9,13-triazapentadecane.
A compound represented by the following Formula (III) or a pharmaceutically acceptable salt thereof:
- wherein:
- p is 1,
- q is 1 or 2,
- R7 represents a hydrogen atom,
- R8 represents a group represented by Formula (IV) below,
- R9 represents a hydrogen atom or a benzyl group,
- R10 represents a hydrogen atom,
- R11 represents a group represented by the following Formula (IV):
- where u is 1 or 2,
- R12 represents a hydrogen atom, and
- R13 represents a cyclopropylmethyl group.
A compound represented by the following Formula (III) or a pharmaceutically acceptable salt thereof:
- wherein:
- p is 1,
- q is 1 or 2,
- R7 represents a hydrogen atom,
- R8 represents a group represented by Formula (IV) below,
- R9 represents a benzyl group,
- R10 represents a hydrogen atom,
- R11 represents a group represented by the following Formula (IV):
- where u is 1 or 2,
- R12 represents a hydrogen atom, and
- R13 represents cyclopropylmethyl group.
A compound represented by the following Formula (III) or a pharmaceutically acceptable salt thereof:
- wherein:
- p is 1,
- q is 1 or 2,
- R7 represents a p-toluenesulfonyl group,
- R8 represents a group represented by Formula (IV) below,
- R9 represents a hydrogen atom or a benzyl group,
- R10 represents a p-toluenesulfonyl group,
- R11 represents a group represented by the following Formula (IV):
- where u is 1 or 2,
- R12 represents a p-toluenesulfonyl group, and
- R13 represents an ethyl group or a cyclopropylmethyl group.
Dependencies are inferred from the claim text.