Analgesic regimen
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsMarc Kamin, William Olson
Life of this patent
Estimating the term…
Abstract
A regimen for the administration of tramadol for the treatment of analgesia is described. The regimen involves a slower initial titration rate of tramadol which results in a significantly lower percentage of discontinuations of therapy due to a lower incidence and severity of side effects.
Claims11
A regimen for the treatment of pain which comprises administering to one in need thereof about 25 mg tramadol on days 1-3;
- about 50 mg of tramadol on days 4-6;
- about 75 mg of tramadol on days 7-9;
- about 100 mg of tramadol on days 10-12;
- about 150 mg of tramadol on days ±3-15;
- about 200 mg of tramadol on days 16-18 and about 200 mg to about 400 mg of tramadol per day thereafter, in the form of a pharmaceutical composition containing tramadol as the active ingredient;
- whereby discontinuations due to adverse side effects are reduced.
A regimen for the treatment of pain which comprises administering to one in need thereof about 25 mg tramadol on days 1-3;
- about 50 mg of tramadol on days 4-6;
- about 75 mg of tramadol on days 7-9;
- about 100 mg of tramadol on days 10-12;
- about 150 mg of tramadol on days ±3-15;
- and about 200 mg on day 16, in the form of a pharmaceutical composition containing tramadol as the active ingredient;
- whereby discontinuations due to adverse side effects are reduced.
A regimen for the treatment of pain which comprises administering to one in need thereof about 25 mg of tramadol on days 1-3;
- about 50 mg of tramadol on days 4-6;
- about 75 mg of tramadol on days 7-9;
- about 100 mg of tramadol on days 10-12;
- about 150 mg of tramadol on days 13-15;
- and about 200 mg on days 16-18, in the form of a pharmaceutical composition containing tramadol as the active ingredient;
- whereby discontinuations due to adverse side effects are reduced.
A regimen for the treatment of pain which comprises administering to one in need thereof about 25 mg tramadol on days 1-3;
- about 50 mg of tramadol on days 4-6;
- about 75 mg of tramadol on days 7-9;
- about 100 mg of tramadol on days 10-12, in the form of a pharmaceutical composition containing tramadol as the active ingredient;
- whereby discontinuations due to adverse side effects are reduced.
A regimen for the treatment of pain which comprises administering to one in need thereof about 25 mg tramadol on days 1-3;
- about 50 mg of tramadol on days 4-6;
- about 75 mg of tramadol on days 7-9;
- about 100 mg of tramadol on days 10-12;
- about 150 mg of tramadol on days 13-15, in the form of a pharmaceutical composition containing tramadol as the active ingredient;
- whereby discontinuations due to adverse side effects are reduced.
A regimen for the treatment of pain which comprises administering to one in need thereof about 25 mg tramadol on days 1-3;
- about 50 mg of tramadol on days 4-6;
- about 75 mg of tramadol on days 7-9;
- about 100 mg of tramadol on days 10-12;
- about 150 mg of tramadol on days 13-15, and thereafter, in the form of a pharmaceutical composition containing tramadol as the active ingredient;
- whereby discontinuations due to adverse side effects are reduced.
Dependencies are inferred from the claim text.