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US 6,605,641 B2Granted
20-HETE antagonists and agonists
AssigneeMCW Research Foundation, Inc.
InventorsRichard J. Roman, John R. Falck, Magdalena Alonso-Galicia, Elizabeth R. Jacobs, David R. Harder
Life of this patent
Estimating the term…
Abstract
20-HETE agonists and antagonists are disclosed along with therapeutic applications. In a preferable form of the invention, the 20-HETE agonists are selected from the group consisting of 21-hydroxyheneicosa-5(Z), 8(Z), 11(Z), 14(Z)-tetraenoic acid, 20-hydroxyeicosa-5(Z), 14(Z)-dienoic acid and 20-, 21-dimethyl 20-HETE. Preferable 20-HETE antagonists include 5(S)-HETE, 15(S)-HETE, 19(S)-HETE, 19-hydroxynonadeca-5(Z), 8(Z), 11(Z), 14(Z)-tetraenoic acid and 20-hydroxyeicosa 6(Z), 15(Z)-dienoic acid.
Claims1
A pharmaceutical preparation comprising:
- a compound selected from (1) 20 hydroxyeicosa-5(Z), 14(Z), dienoic acid,(2) 20 hydroxyeicosa-6(Z), 15(Z)-dienoic acid, (3) N-methylsulfonyl-20-hydroxyeicosa-5(Z), 14(Z)-dienamide or (4) N-methylsulfonyl-20-hydroxyeicosa-6(Z), 15(Z)-dienamide;
- and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.