Modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof
AssigneeThe Salk Insitute for Biological Studies
InventorsRonald M. Evans, Barry M. Forman
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Abstract
In accordance with the present invention, there is provided a class of compounds which are capable of modulating processes mediated by peroxisome proliferator activated receptor-gamma (PPAR-γ). The identification of such compounds makes it possible to intervene in PPAR-γ mediated pathways.
Claims20
A method for modalating the formation of macrophages involved in the development of atherosclerotic plaques in a subject, said method comprising administering to said subject an amount of at least one peroxisome proliferator activated receptor-gamma (PPAR-γ) antagonist or partial-agonist sufficient to modulate said formation.
A method for modulating the development of atherosclerotic plaques in a subject, said method comprising administering to said subject an amount of at least one peroxisome proliferator activated receptor-gamma (PPAR-γ) antagonist or partial-agonist sufficient to modulate said development.
Dependencies are inferred from the claim text.