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US 6,605,612 B2Granted
Cardioprotective phosohonates and malonates
AssigneeMedicure International Inc.
InventorWasimul Haque
Life of this patent
Estimating the term…
Abstract
The present invention provides for pyridoxine phosphonate analogues such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)alkylphosphonates, and and (2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridyl)azaalkylphosphonates) and to pyridoxine malonate analogues, such as, for example, ((2-methyl-3-hydroxy-4-hydroxymethyl-5-pyridylmethyl)malonates), pharmaceutical compositions, and methods for treatment of cardiovascular and related diseases, and diabetes mellitus and related diseases.
Claims10
A compound of the formula I
- in which
- R1 is hydrogen or alkyl;
- R2 is —CH2OH, —CH3, —CO2R6 in which R6 is hydrogen, alkyl, or aryl;
- or
- R2 is —CH2-O-alkyl- in which alkyl is covalently bonded to the oxygen at the 3-position instead of R1;
- R3 is hydrogen and R4 is hydroxy, halo, alkoxy, alklcarbonyloxy, alkylamino or arylamino;
- or
- R3 and R4 are halo;
- and
- R5 is hydrogen, alkyl, aryl, aralkyl, or —CO2R7 in which R7 is hydrogen, alkyl, aryl, or aralkyl;
- or a pharmaceutically acceptable acid addition salt thereof.
8 more elements
Dependencies are inferred from the claim text.