Carboxylic and hydroxamic acid compounds inhibiting metalloproteases, method for preparing same and pharmaceutical compositions containing them

A compound selected from those of formula (I):

• wherein:
• n is 0 or 1,
• R1, R2, R3 and R4 independently represent hydrogen or alkyl, or
• R1 and R3 form together with the carbon atoms carrying them a (C5-C8)cycloalkyl and in that case R2 and R4 each represents hydrogen,
• R5 and R6 form together with the nitrogen and Z carrying them a saturated, partially unsaturated or unsaturated mono-, bi-, or tri-cyclic group having 5 to 16 ring members and 1 to 7 hetero atoms selected from nitrogen, oxygen and sulphur and/or sulphoxide or sulphone, the cyclic group being optionally substituted by 1 to 7 identical or different substituents selected fro halogen, alkyl, amino, hydroxy, alkoxy, nitro, mercapto, alkylthio, cyano, oxo, imino, thioxo, carboxy, alkoxycarbonyl and aminocarbonyl (optionally substituted on the nitrogen atom by one or two alkyl groups),
• R10 represents hydrogen or hydroxy, and in the latter case R1, R2, R3 and R4 are independently selected from hydrogen and alkyl,
• Z represents —CO— or —SO2—,
• Y represents hydroxy, alkoxy, alkenyloxy or benzyloxy or —NH—OR wherein R represents hydrogen or alkyl, alkenyl or benzyl,
• X represents:
• sulphur or —SO— or —SO2— and in those cases R3 and R4 are other than alkyl, or X represents —COO— and in that case R1 and R3 together form (C5-C8)cycloalkyl, or X represents oxygen,
• W represents W1—(A)p or W1—B—W2—(A)p wherein W1 and W2 independently represent aryl or heteroaryl, the A substituent of the aromatic cyclic is attached at any of the positions of that cyclic group and represents halogen or alkyl, alkoxy, hydroxy, mercapto, cyano, amino, nitro, cyanoalkyl or thioalkyl, B represents a bond, oxygen or alkylene, alkenylene or alkynylene (wherein any one of the carbon atoms of the alkylene, alkenylene or alkynylene may be replaced by oxygen), and p represents integer of 0 to 5 inclusive,
• T1 and T2 independently represent a bond or alkylene, alkenylene or alkynylene,
• wherein when T2 represents a bond and n is 0 and at the same time R1, R2, R3 and R4 each represents hydrogen, then R5 and R6 form together with nitrogen and the group Z carrying them a bicyclic as defined hereinbefore that is other than 1,3-dioxo-2,3-dihydro-1H-2-isoindolyl, 2,5-pyrrolidinedione or optionally substituted 2,5-dioxo-1-imidazolinyl,
• its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base.