Uses of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid
AssigneesGador S.A., University of Leiden
InventorsEmilio J. A. Roldan, Anibal Perez-Lloret, Guillermo Vazquez, Ricardo Boland, Sokrates E. Papapoulos
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Abstract
The present invention relates to novel uses of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid or any of its soluble salts or any of its hydrates, in particular its use for the manufacture of a medicament for selective modulation of osteoblasts.
Claims3
A method for stimulation of the cellular activities of osteoblasts, said method consisting of administering to a patient an osteblast stimulating effective amount of a pharmaceutical composition consisting of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid, any of its pharmaceutical acceptable soluble salts or any of its pharmaceutical acceptable hydrates as an active agent.
A method for stimulation of the cellular activities of osteoblasts for influencing a Ca2−-homeostasis of the osteoblasts, said method consisting of:
- administering to a patient an osteoblast stimulating effective amount of a pharmaceutical composition consisting of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid, any of its pharmaceutical acceptable soluble salts or any of its pharmaceutical acceptable hydrates as an active agent.
A method for stimulation of the cellular activities of osteoblasts for inducing a transient increase of the Ca2+-levels in the osteoblasts, said method consisting of:
- administering to a patient an osteoblast stimulating effective amount of a pharmaceutical composition consisting of 1-amino-3-(N,N-dimethylamino)-propylidene-1,1-bisphosphonic acid, any of its pharmaceutical acceptable soluble salts or any of its pharmaceutical acceptable hydrates as an active agent.
Dependencies are inferred from the claim text.