Method of treating BK virus nephropathy
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorAbhay N. Vats
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Abstract
Provided are oligonucleotides for the quantitation of BK virus (BKV) viral loads in a sample and methods for the diagnosis and management of BKV-associated nephropathy using PCR or QPCR methods. In addition, a PCR method for quantitating the BKV viral load in urine, serum and tissue using the described nucleic acid primers is also disclosed. Furthermore, a method for the management of BKV-associated nephropathy in renal transplant recipients using cidofovir is disclosed. Lastly, a kit is provided containing the described PCR for use in diagnosing and managing BKV-associated nephropathy.
Claims10
A method of managing BKV-associated nephropathy in a renal transplant patient comprising administering to the renal transplant patient a dose of cidofovir effective to reduce BKV viral load in the patient.
A method of managing BKV-associated nephropathy in a renal transplant patient comprising the steps of:
- (a) quantitating the BKV viral load in a specimen of the patient;
- and
- b) administering to the patient a dose of cidofovir effective to reduce BKV viral load in the patient, wherein the amount of cidofovir administered to the patient is based upon at least one of the BKV viral load in the specimen, the response of the BKV viral load in the patient to previous administrations of cidofovir and patient creatinine levels.
A method of treating BKV-associated nephropathy in a renal transplant patient comprising administering to the renal transplant patient a dose of cidofovir effective to reduce BKV viral load in the patient.
Dependencies are inferred from the claim text.