Back to results
US 6,605,597 B1Granted
Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives
AssigneeCV Therapeutics, Inc.
InventorsJeff A. Zablocki, Venkata P. Palle, Vaibhav Varkhedkar, Luiz Belardinelli
Life of this patent
Estimating the term…
Abstract
N6 heterocyclic 5′ modified adenosine derivatives that are adenosine A1 receptor partial or full agonists, and as such, are useful for modifying cardiac activity, modifying adipocyte function, treating central nervous system disorders, and treating diabetic disorders and obesity in mammals, and especially in humans.
Claims13
A compound of the formula:
- wherein:
- R1 is tetrahydrofuran-3-yl;
- R2 is hydrogen;
- R3 and R4 are hydrogen;
- R5 is phenyl, optionally substituted with halo, alkyl of 1-5 carbon atoms, alkoxy of 1-5 carbon atoms, or trifluoromethyl;
- and
- X1 is S;
- or a pharmaceutically effective salt thereof.
5 more elements
Dependencies are inferred from the claim text.