Low density lipoprotein binding proteins and their use in diagnosing and treating atherosclerosis
AssigneeBoston Heart Foundation, Inc.
InventorsAnn M. Lees, Robert S. Lees, Simon W. Law, Anibal A. Arjona
Life of this patent
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Abstract
Isolated polynucleotides encoding novel polypeptides which are capable of binding to native and methylated LDL (low density lipoprotein), the isolated polypeptides, called LBPs (LDL binding proteins), and biologically active fragments and analogs thereof, are described. Also described are methods for determining if an animal is at risk for atherosclerosis, methods for evaluating an agent for use in treating atherosclerosis, methods for treating atherosclerosis, and methods for treating a cell having an abnormality in structure or metabolism of LBP. Pharmaceutical compositions and vaccine compositions are also provided.
Claims22
A method of treating a subject having atherosclerosis or at risk for having atherosclerosis, the method comprising:
- providing a subject having atherosclerosis or at risk for having atherosclerosis;
- and
- administering to the subject a polypeptide and an adjuvant, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO:6 or an immunogenic fragment of the amino acid sequence of SEQ ID NO:6.
A pharmaceutical composition comprising a polypeptide mixed with an adjuvant, suitable for use in humans, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO:6, SEQ ID NO:9, SEQ ID NO:23, or SEQ ID NO:24.
Dependencies are inferred from the claim text.