Methods for avoiding maternal immunity
AssigneeHealth Research, Inc.
InventorEnzo Paoletti
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Abstract
What is described is a recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, containing foreign DNA from herpesvirus. In one embodiment, the foreign DNA is expressed in a host by the production of a herpesvirus glycoprotein. In another embodiment, the foreign DNA is expressed in a host by the production of at least two, particularly two or three, herpesvirus glycoproteins. What is also described is a vaccine containing the recombinant poxvirus for inducing an immunological response in a host animal inoculated with the vaccine. By the present invention, the barrier of maternal immunity in a newborn offspring can be overcome or avoided.
Claims39
A method for avoiding maternal immunity in a newborn offspring, which method comprises inoculating the newborn offspring with a recombinant poxvirus containing therein DNA from a non-pox source in a nonessential region of the poxvirus genome, said DNA coding for a first antigen of a pathogen of the newborn offspring, said antigen being different from a second antigen of the same pathogen used to induce an immunological response to the same pathogen in the mother of the newborn offspring, wherein the mother is a cow, horse, pig or cat, and the poxvirus is a vaccinia virus of an avipox virus.
A method for avoiding maternal immunity in a newborn offspring, which method comprises inoculating the newborn offspring with a recombinant first poxvirus containing therein DNA from a non-pox source in a nonessential region of the first poxvirus genome, said DNA coding for an antigen of a pathogen of the newborn offspring, said first poxvirus being different from a recombinant second poxvirus used to induce an immunological response to the same pathogen in the mother of the newborn offspring, wherein the mother is a cow, horse, pig or cat, and the poxvirus is a vaccinia virus of an avipox virus.
Dependencies are inferred from the claim text.