Nucleic acids encoding IKR-2, a protein kinase related to the I kappa B kinases

An isolated polynucleotide molecule encoding a polypeptide having kinase activity, the polynucleotide molecule comprising a nucleotide sequence selected from the group consisting of:

• (a) a nucleotide sequence encoding an amino acid sequence selected from the group consisting of amino acids 1 through 53 of SEQ ID NO:4, amino acids 1 through 300 of SEQ ID NO:4, amino acids 2 through 53 of SEQ ID NO:4, amino acids 143 through 234 of SEQ ID NO:4, amino acids 185 through 234 of SEQ ID NO:4, amino acids 185 through 309 of SEQ ID NO:4, amino acids 310 through 319 of SEQ ID NO:4, amino acids 310 through 414 of SEQ ID NO:4, amino acids 320 through 414 of SEQ ID NO:4, amino acids 320 through 439 of SEQ ID NO:4, amino acids 415 through 439 of SEQ ID NO:4, amino acids 415 through 486 of SEQ ID NO:4, amino acids 440 through 486 of SEQ ID NO:4, amino acids 440 through 598 of SEQ ID NO:4, amino acids 487 through 598 of SEQ ID NO:4, amino acids 487 through 620 of SEQ ID NO:4, amino acids 599 through 620 of SEQ ID NO:4, amino acids 599 through 623 of SEQ ID NO:4, amino acids 624 through 662 of SEQ ID NO:4, amino acids 624 through 673 of SEQ ID NO:4, amino acids 663 through 673 of SEQ ID NO:4, amino acids 663 through 686 of SEQ ID NO:4, amino acids 674 through 686 of SEQ ID NO:4, and amino acids 674 through 690 of SEQ ID NO:4;
• (b) a nucleotide sequence of (a), wherein said nucleotide sequence is a fragment of SEQ ID NO:3;
• (c) the nucleotide sequence of a polynucleotide molecule, or its complement, that hybridizes to a denatured DNA molecule comprising the nucleotide sequence of (b) in 50% formamide and 6×SSC at 42 degrees C., and washing in 0.2×SSC and 0.1% SDS at 68 degrees C., wherein the nucleotide sequence encodes a polypeptide having kinase activity;
• and
• (d) a nucleotide sequence that is at least 90% identical to the nucleotide sequence of (b), wherein the nucleotide sequence encodes a polypeptide having kinase activity.