Back to results
US 6,605,295 B1Granted
Storage-stable ophthalmic compositions comprising diclofenac and ofloxacin
AssigneeBausch & Lomb Incorporated
InventorsGunther Bellmann, Gudrun Claus-Herz, Christoph Kessler
Life of this patent
Estimating the term…
Abstract
The invention relates to stable ophthalmic preparations including the penetrant antiphlogistic diclofenac or salts thereof and the penetrant antibiotic ofloxacin present in the form of the racemate, an enantiomer, particularly levofloxacin, or the corresponding hydrochloride thereof. The preparations may be used for treating eye infections and/or inflammations and for preventing infections before and after eye surgery.
Claims12
A stable ophthalmic composition for topical administration to eye tissue comprising:
- 0.001 to 0.15 weight percent of diclofenac or a salt thereof;
- 0.01 to 0.5 weight percent of ofloxacin or the hydrochloride thereof;
- 0.001 to 0.02 weight percent of sodium disulphite;
- 0 to 5 weight percent of povidone;
- 0 to 2 weight percent of polysorbate;
- 0 to 5 weight percent of sodium chloride;
- 0 to 10 weight percent of sorbitol;
- 0 to 1.0 weight percent of benzalkonium chloride;
- 0 to 0.002 weight percent of sodium edetate;
- an alkali hydroxide or acid in an amount effect to adjust a pH value of the composition to a value greater than about 7;
- and
- water.
9 more elements
Dependencies are inferred from the claim text.