Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
AssigneeIncept, LLC
InventorAmarpreet S. Sawhney
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Abstract
Pharmaceutically acceptable hydrogel polymers of natural, recombinant or synthetic origin, or hybrids thereof, are introduced in a dry, less hydrated, or substantially deswollen state and rehydrate in a physiological environment to undergo a volumetric expansion and to affect sealing, plugging, or augmentation of tissue, defects in tissue, or of organs. The hydrogel polymers may deliver therapeutic entities by controlled release at the site. Methods to form useful devices from such polymers, and to implant the devices are provided.
Claims10
A method for anchoring an implant in a lumen or void in a body comprising:
- providing an article having at least one rod shaped portion polymerized from at least one macromer, the portion comprising a pharmaceutically acceptable crosslinked hydrogel that is absorbable in vivo, the rod portion having a first state wherein the hydrogel is at substantially less than an equilibrium level of hydration, and a second state wherein the hydrogel is substantially at the equilibrium level of hydration, the rod shaped portion undergoing volumetric expansion while transitioning to the second state;
- positioning the rod shaped portion in the lumen or void in the first state;
- and
- hydrating the rod shaped portion to transition the hydrogel to the second state so that the rod shaped portion undergoes sufficient volumetric expansion to become anchored within and occlude the lumen or void.
A method for anchoring an implant in a rack in a body created by a biopsy device, the method comprising positioning at least a portion of an article in the track that is comprised of a pharmaceutically acceptable cross-linked synthetic hydrogel that absorbs fluid from the body and thereby undergoes sufficient volumetric expansion to become anchored within the track, wherein the hydrogel is polymerized from at least one macromer and is absorbable in vivo.
Dependencies are inferred from the claim text.