Interleukin-18 binding proteins, their preparation and use for blocking the activity of IL-18
AssigneeYeda Research and Development Co. Ltd.
InventorsDaniela Novick, Charles Dinarello, Menachem Rubinstein, Soo Hyun Kim
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Abstract
Interleukin-18 binding proteins which are capable of binding IL-18 and/or modulating and/or blocking IL-18 activity are provided. Methods for their isolation and recombinant production, DNAs encoding them, DNA vectors expressing them, vectors useful for their expression in humans and other mammals, antibodies against them are also provided.
Claims24
An isolated IL-18 binding protein (IL-18BP) selected from the group consisting of:
- (a) a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 2 or 6;
- and
- (b) a polypeptide as defined in (a) without a leader sequence.
An isolated IL-18 binding protein (IL-18BP) wherein the IL-18BP comprises the amino acid sequence of SEQ ID NO:10 and is selected from the group consisting of:
- (a) a polypeptide comprising the amino acid sequence of SEQ ID NO:2 or 6;
- (b) a polypeptide as defined in (a) without a leader sequence;
- (c) a mutein of the polypeptide defined in (a) or (b), characterized in that the mutein has at least 90% sequence identity to SEQ ID NO:
- 2 or 6, and binds IL-18.
An isolated protein selected from the group consisting of:
- (a) a polypeptide comprising the amino acid sequence of SEQ ID NO:
- 4 or 8;
- and
- (b) a polypeptide as defined in (a) without a leader sequence.
Dependencies are inferred from the claim text.