Uses of trank, a novel secretory cytokine
AssigneeResearch Development Foundation
InventorBharat B. Aggarwal
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Abstract
The present invention provides methods for the therapeutic application of TRANK, a novel cytokine. TRANK is secreted by cells and activates NF-κB, c-Jun N-terminal kinase (JNK) and downstream gene products. Provided is a method of inhibiting NF-κB activation in an individual in need of such treatment, comprising the step of administering an effective dose of an anti-TRANK antibody to said individual.
Claims3
A method of inhibiting TRANK-mediated NF-κB activation in an individual in need of such treatment, comprising the step of administering an effective dose of an anti-TRANK antibody to said individual, wherein said antibody reacts with human TRANK (thioredoxin peroxidase-related activator of NF-κB and c-Jun N-terminal kinase) protein of SEQ ID No. 1, and wherein binding of said antibody to said TRANK protein inhibits TRANK-mediated activation of NF-κB.
A method for treating a pathophysiological state in a human wherein said state has an undesirable level of TRANK-mediated NF-κB activation, comprising the step of administering to said human an effective dose of an anti-TRANK antibody, wherein said antibody reacts with human TRANK (thioredoxin peroxidase-related activator of NF-κB and c-Jun N-terminal kinase) protein of SEQ ID No. 1, and wherein binding of said antibody to said TRANK protein inhibits TRANK-mediated activation of NF-κB.
Dependencies are inferred from the claim text.