Method for in vivo regulation of cardiac muscle contractility
AssigneeThe Regents of the University of California
InventorsWolfgang H. Dillmann, Frank Giordano, Ruben Mestril
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Abstract
A method for regulating in vivo calcium transport in cardiac muscle of animals suffering from congestive heart failure is disclosed. According to the method, calcium ATPase activity (which decreases as congestive heart failure develops) and cardiac muscle contractility augmented by delivering a gene which operatively encodes the enzyme into the heart. Delivery systems (including recombinant expression vectors) are provided, as are methods for monitoring the expression and effect of the gene product on cardiac performance.
Claims4
A method for augmenting SERCA2 mediated calcium ion transport into the sarcoplasmic reticulum of cardiac myocytes of a host, the method comprising delivering an adenoviral recombinant expression vector containing a SERCA2 encoding transgene into host cardiac muscle, wherein expression of the transgene induces an augmentation in SERCA2 mediated calcium ion transport in treated myocytes, as compared to untreated myocytes.
Dependencies are inferred from the claim text.