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US 6,605,222 B1Granted
Method for producing a factor VIII/von Willebrand factor complex
AssigneeBaxter Aktiengesellschaft
InventorsYendra Linnau, Wolfgang Schoenhofer
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Abstract
The invention relates to a method for the production of factor VIII:C/von Willebrand factor complex from plasma or a plasma fraction by chromatography in a cation exchanger, wherein the factor VIII:C/von Willebrand factor complex is obtained with at least 300 times the purity of the plasma and the yield of factor VIII:C and the von Willebrand factor is at least 50% in relation to cryoprecipitates or analogous plasma fractions.
Claims9
A method for producing a preparation containing factor VIII:C/vWF complex, said method comprising:
- treating a starting material containing a factor VIII:C/vWF complex, wherein the starting material is selected from the group consisting of plasma and a plasma fraction, with a cation exchanger, where the factor VIII:C/vWF complex is bonded to the cation exchanger;
- separating unbonded starting material;
- and
- eluting the factor VIII:C/vWF complex from the cation exchanger, wherein chromatography on the cation exchanger is the only chromatographic purification.
1 more element
Dependencies are inferred from the claim text.