Back to results
US 6,605,200 B1Granted
Polymeric transition metal complexes and uses thereof
AssigneeTheraSense, Inc.
InventorsFei Mao, Adam Heller
Life of this patent
Estimating the term…
Abstract
Novel polymeric transition metal complexes of iron, cobalt, ruthenium, osmium, and vanadium are described. The polymeric transition metal complexes can be electron transfer mediators in enzyme-based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor.
Claims21
A polymeric transition metal complex, comprising:
- a polymeric backbone;
- a plurality of spacers, each spacer covalently coupled to and extending from the polymeric backbone, each spacer comprising at least one non-cyclic functional group selected from the group consisting of —(CRrRs)—, —O—, —S—, —C(O)O—, —S(O)2NRk—, —OC(O)NRm—, —OC(S)NRn, —C(O)NRt—, —NRu—, —CRv═N—O—, —CRw═NNRx—, and —(SiRyRz)—, wherein Rr and Rs are independently hydrogen, chlorine, fluorine, or substituted or unsubstituted alkyl, alkoxy, alkenyl, or alkynyl and Rk, Rm, Rn, Rt, Ru, Rv, Rw, Rx, Ry, and Rz are independently hydrogen or substituted or unsubstituted alkyl;
- and
- a plurality of transition metal complexes, each transition metal complex having the formula:
- wherein M is osmium;
- L1 is a ligand comprising a heterocycle and is coordinatively bound to M via a heteroatom of the heterocycle;
- L2, L3, L4, L5, and L6 are ligands comprising a nitrogen-containing heterocycle, wherein each of L1, L2, L3, L4, L5, and L6 is independently a monodentate ligand or combined with at least one other ligand to form a multidentate ligand;
- and
- wherein at least one of L1, L2, L3, L4, L5, and L6 is covalently coupled to a one of the spacers.
6 more elements
A polymeric transition metal complex comprising:
- a polymeric backbone;
- a plurality of spacers, each spacer covalently coupled to and extending from the polymeric backbone, each spacer comprising at least four non-cyclic functional groups selected from the group consisting of —(CRrRs)—, —O—, —S—, —S(O)2NRk—, —OC(O)NRm—, —OC(S)NRn, —C(O)NRt—, and —NRu—, wherein Rk, Rm, Rn, Rr, Rs, Rt, and Ru are independently selected from the group consisting of hydrogen and substituted or unsubstituted alkyl;
- a plurality of transition metal complexes, each transition metal complex having the formula:
- wherein M is osmium;
- L1 is a ligand comprising a heterocycle and is coordinatively bound to M via a heteroatom of the heterocycle;
- L2, L3, L4, L5, and L6 are ligands, wherein each of L1, L2, L3, L4, L5, and L6 independently a monodentate ligand or combined with at least one other ligand to form a multidentate ligand;
- and
- wherein at least one of L1, L2, L3, L4, L5, and L6 is covalently coupled to a one of the spacers.
5 more elements
A polymeric transition metal complex, comprising:
- a polymeric backbone;
- a plurality of spacers, each spacer covalently coupled to and extending from the polymeric backbone, each spacer comprising a flexible chain of at least four atoms;
- a plurality of transition metal complexes, each transition metal complex having the formula:
- wherein M is osmium;
- L1 is a ligand comprising a heterocycle and is coordinatively bound to M via a heteroatom of the heterocycle;
- L2, L3, L4, L5, and L6 are ligands comprising a nitrogen-containing heterocycle, wherein each of L1, L2, L3, L4, L5, and L6 is independently a monodentate ligand or combined to form one or more multidentate ligands;
- and
- wherein at least one of L1, L2, L3, L4, L5, and L6 is covalently coupled to a one of the spacers.
5 more elements
A redox mediator, comprising:
- a polymeric backbone;
- a plurality of spacers, each spacer covalently coupled to and extending from the polymeric backbone, each spacer comprising at least one non-cyclic functional group selected from the group consisting of —(CRrRs)—, —O—, —S—, —C(O)O—, —S(O)2NRk—, —OC(O)NRm—, —OC(S)NRn, —C(O)NRt—, —NRu—, —CRv═N—O—, —CRw═NNRx—, and —(SiRyRz)—, wherein Rr and Rs are independently hydrogen, chlorine, fluorine, or substituted or unsubstituted alkyl, alkoxy, alkenyl, or alkynyl and Rk, Rm, Rn, Rt, Ru, Rv, Rw, Rx, Ry, and Rz are independently hydrogen or substituted or unsubstituted alkyl;
- a plurality of transition metal complexes, each transition metal complex having the formula:
- wherein M is osmium;
- L1 is a ligand comprising a heterocycle and is coordinatively bound to M via a heteroatom of the heterocycle;
- L2, L3, L4, L5, and L6 are ligands comprising a nitrogen-containing heterocycle, wherein each of L1, L2, L3, L4, L5, and L6 is independently a monodentate ligand or combined with at least one other ligand to form a multidentate ligand;
- and
- wherein at least one of L1, L2, L3, L4, L5, and L6 is covalently coupled to a one of the spacers.
5 more elements
A sensor comprising:
- a working electrode;
- a counter electrode;
- and
- a redox mediator disposed proximate to the working electrode, the redox mediator comprising
- a polymeric backbone,
- a plurality of spacers, each spacer covalently coupled to and extending from the polymeric backbone, each spacer comprising at least four non-cyclic functional groups selected from the group consisting of —(CRrRs)—, —O—, —S—, —S(O)2NRk—, —OC(O)NRm—, —OC(S)NRn, —C(O)NRt—, and —NRu—, wherein Rk, Rm, Rn, Rr, Rs, Rt, and Ru are independently selected from the group consisting of hydrogen and substituted or unsubstituted alkyl;
- a plurality of transition metal complexes, each transition metal complex having the formula:
- wherein M is osmium,
- L1 is a ligand comprising a heterocycle and is coordinatively bound to M via a heteroatom of the heterocycle,
- L2, L3, L4, L5, and L6 are ligands, wherein each of L1, L2, L3, L4, L5, and L6 is independently a monodentate ligand or combined with at least one other ligand to form a multidentate ligand, and
- wherein at least one of L1, L2, L3, L4, L5, and L6 is covalently coupled to a one of the spacers.
8 more elements
Dependencies are inferred from the claim text.