Synthetic bone matrix
AssigneeStryker Corporation
InventorsThangavel Kuberasampath, Lawrence Berlowitz Tarrant
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Abstract
Disclosed is an osteogenic device capable of inducing the formation of endochondral bone in a shape conforming substantially to the shape of the device when implanted in a mammalian host. The device includes an osteogenic protein dispersed within a porous matrix comprising a polymer of collagen and glycosaminoglycan cross-linked to an MC value of about 800 to about 60,000. Also disclosed are a method of inducing mammalian bone growth, and a method of inducing conductive bone growth from viable mammalian bone.
Claims9
An osteogenic device for inducing cartilage or endochondral bone formation in a mammal, the device comprising:
- (a) a polymer comprising a glycosaminoglycan, and
- (b) an isolated osteogenic protein comprising at least seven cysteine residues in the same relative positions as the seven cysteine skeleton sequence:
- 1 10 20 30 40 50 CXXXXLXVXFXDXGWXXWXXXPXGXXAXYCXGXCXXPXXXXXXXXNHAXX 60 70 80 90 100 QXXVXXXNXXXXPXXCCXPXXXXXXXXLXXXXXXXVXLXXYXXMXVXXCX CX
- wherein each X is an amino acid, such that the osteogenic protein induces local bone or cartilage formation in a mammal when implanted with the polymer in the mammal.
An osteogenic device for inducing cartilage or endochondral bone formation in a mammal, the device comprising:
- (a) a polymer comprising a glycosaminoglycan, and
- (b) an isolated osteogenic protein comprising an amino acid sequence sufficiently duplicative of SEQ ID NO:
- 1 such that the osteogenic protein induces local bone or cartilage formation when implanted with the polymer in a mammal.
An osteogenic device for inducing cartilage or endochondral bone formation in a mammal, the device comprising:
- a) an isolated osteogenic protein comprising OP-1 and
- b) a polymer comprising a glycosaminoglycan.
Dependencies are inferred from the claim text.