Method and composition for inhibiting cardiovascular cell proliferation
AssigneeThe Board of Trustees of the Leland Stanford Junior University
InventorsJohn P. Cooke, Garrison C. Fathman, Jonathan B. Rothbard, Shiro Uemura, Robert C. Robbins, Murray H. Kown
Life of this patent
Estimating the term…
Abstract
Cardiovascular cell proliferation in a blood vessel subjected to trauma, such as angioplasty, vascular graft, anastomosis, or organ transplant, can be inhibited by contacting the vessel with a polymer consisting of from 6 to about 30 amino acid subunits, where at least 50% of the subunits are arginine, and the polymer contains at least six contiguous arginine subunits. Exemplary polymers for this purpose include arginine homopolymers 7 to 15 subunits in length.
Claims28
A method for inhibiting trauma-induced intimal hyperplasia in a graft or vascular vessel receiving a graft, comprising:
- contacting a graft, prior to grafting, with a polymer consisting of from 6 to about 30 amino acid subunits in a pharmaceutically acceptable vehicle, wherein at least 50% of said subunits are arginine residues, and said polymer contains at least six contiguous arginine residues.
A method of increasing NO production in a graft or vascular vessel receiving a graft, comprising contacting the graft, prior to grafting, with a polymer consisting of from 6 to about 30 amino acid subunits, wherein at least 50% of said subunits are arginine residues, and said polymer contains at least six contiguous arginine residues, in a pharmaceutically acceptable vehicle.
Dependencies are inferred from the claim text.