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US 6,603,127 B1Granted
Bismuth-213 generator and uses thereof
AssigneeSloan-Kettering Institute for Cancer Research
InventorsDavid Scheinberg, Ronald D. Finn, Dangshe Ma, Michael R. McDevitt
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Abstract
The present invention provides a generator capable of producing therapeutic Bismuth-213 doses. Also disclosed are methods of preparing Bismuth-213-labeled compounds using such generator and applications of the labeled compounds.
Claims38
A bismuth-213 generator, comprising:
- a first container containing 225Ac solution;
- a second container;
- a generator column;
- a valve, said valve simultaneously and directly connected to an end of each of said first container, said second container and said column;
- and a third container, said third container connected to said generator column at an exit end opposite to the end connected to said valve.
2 more elements
A kit for preparing a bismuth-213-labeled compound, wherein said kit comprises:
- (a) a bismuth-2 13 generator, comprising:
- a first container containing 225Ac solution;
- a second container;
- a generator column;
- a valve, said valve simultaneously and directly connected to an end of each of said first container, said second container and said column;
- and
- a third container, said third container connected to said generator column at an exit end opposite to the end connected to said valve;
- and
- (b) a fourth container to contain an eluant;
- a reaction vial to contain said unlabeled compound premixed with a neutralizing buffer;
- a fifth container to contain a quenching solution;
- purification means;
- and
- a sixth container, said sixth container collecting a final product, wherein said final product contains said bismuth-213-labeled compound.
11 more elements
Dependencies are inferred from the claim text.