Process for the preparation of (schiff bases of) α-alkyl-α-amino acid amides
AssigneeDsm N.V.
InventorsDominique Monique Charles Callant, Daniel Mink, Anna Maria Cornelia Francisca Castelijns
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Abstract
Process for the preparation of a Schiff base of an α-alkyl-α-amino acid amide and an aldehyde, wherein the corresponding α-aminonitrile is contacted with a base and the aldehyde and wherein it is ensured that the reagents are in good contact. The Schiff base obtained may be further hydrolysed to form the α-alkyl-α-amino acid amide and the aldehyde. Preferably a substituted or unsubstituted benzaldehyde is used as the aldehyde. The reaction is preferably carried out in a practically homogeneously mixed phase obtained by using a solvent, for example methanol or ethanol. Preferably NaOH or KOH is used as the base.
Claims18
A process for the preparation of a Schiff base formed with an α-alkyl-α-amino acid amide (which is an α amino acid amide which lacks any H coupled directly to the α carbon), and an aldehyde, comprising reacting the corresponding α-alkyl-α-aminonitrile with a base and the aldehyde with sufficient mixing that the reaction mixture is maintained without de-mixing in a substantially homogeneous condition.
A process for the preparation of a Schiff base formed with an α-alkyl-α-amino acid amide which is an α amino acid amide which lacks any H coupled directly to the α carbon, and an aromatic aldehyde, comprising
- reacting the corresponding α-alkyl-αaminonitrile with a base and the aromatic aldehyde with sufficient mixing that the reaction mixture is maintained without de-mixing in a substantially homogeneous condition.
Dependencies are inferred from the claim text.