Bicyclic enamide derivatives

A compound of formula (1):

• wherein
• R1 is a group Ar1L2Ar2Alk- in which Ar1 is an optionally substituted aromatic or heteroaromatic group, L2 is a covalent bond or a linker atom or group, Ar2 is an optionally substituted arylene or heteroarylene group and Alk is a chain —CH2—CH(R)—, —CH═C(R)— or
• in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof;
• R2 is a hydrogen atom or a C1-6alkyl group;
• X is an O or S atom or the group NR30 in which R30 is an optionally substituted aliphatic, heteroaliphatic, cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group;
• j and k is each zero or the integer 1 or 2 provided that the sum of j and k is zero or the integer 1 or 2;
• Cy1 is an optionally substituted cycloaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group which incorporates two adjacent carbon atoms of the ring Cy within its ring structure such that the bond between these two atoms may be saturated or unsaturated;
• Rz which may be present on any available carbon atom of the ring Cy is selected from a halogen atom or -(Alk4)vL1(Alk1)n(R3)s atom or group in which Alk4 is a straight or branched C1-3alkylene chain, v is zero or the integer 1, L1 is a covalent bond or a linker atom or group, n is zero or the integer 1, Alk1 is an optionally substituted aliphatic chain, s is the integer 1, 2 or 3 and R3 is a hydrogen atom or a —CN, —NO2 or optionally substituted heteroaliphatic, cycloaliphatic, heterocycloaliphatic, polycyclo-aliphatic, heteropolycycloaliphatic, aromatic or heteroaromatic group provided that when v and n are zero and L1 is a covalent bond and s is the integer 1;
• p is zero or the integer 1, 2 or 3;
• and the salts, solvates, hydrates and N-oxides thereof.