1-imidazolyl substituted tetrahydronaphthalene derivatives as inhibitors of eytochrome P450RAI

A compound of the formula

• wherein
• A is a phenyl or naphthyl group, or heteroaryl selected from a group consisting of pyridyl, thienyl, furyl, pyridazinyl, pyrimidinyl, pyrazinyl, thiazolyl, oxazolyl, imidazolyl and pyrazolyl said phenyl, naphthyl and heteroaryl groups being optionally substituted with one or two R2 groups;
• X1 is 1-imidazolyl, or lower alkyl or halogen substituted 1-imidazolyl;
• Y is H, alkyl of 1 to 10 carbons, benzyl, lower alkyl or halogen substituted benzyl,
• fluoro-substituted alkyl of 1 to 10 carbons, cycloalkyl of 3 to 6 carbons, lower alkyl
• substituted cycloallcyl of 3 to 6 carbons, Cl, Br, or I;
• Z is —C≡C—,
• —(CR1═CR1)n′ where n′ is an integer having the value 1-5,
• —CO—NR1—,
• NR1—CO—,
• —CO—O—,
• —O—CO—,
• —CS—NR1—,
• NR1—CS—,
• —CO—S—,
• —S—CO— or
• —N═N—;
• R1 is independently H or alkyl of 1 to 6 carbons;
• R2 is independently H, alkyl of 1 to 6 carbons, F, Cl, Br, I, fluoro substituted alkyl of 1 to 6 carbons, alkoxy of 1 to 6 carbons, or alkylthio of 1 to 6 carbons;
• R3 is independently alkyl of 1 to 6 carbons, F, Cl, Br, I, fluoro substituted alkyl of 1 to 6 carbons, OH, SH, alkoxy of 1 to 6 carbons, alkylthio of 1 to 6 carbons or benzyl;
• m is an integer having the values 0 to 2;
• R4 is independently H, alkyl of 1 to 6 carbons, or F;
• fluorosubstituted alkyl of 1 to 6 carbons, or halogen;
• o is an integer having the values of 0 to 4;
• n is an integer having the values of 0 to 4, and
• R8 is H, alkyl of 1 to 6 carbons or —CH2O(C1-6-alkyl), or a cation of a pharmaceutically acceptable base.