Process for the preparation of N-carboxyanhydrides
AssigneeIsochem
InventorsFabrice Cornille, Marc Lebon
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Abstract
The invention relates to an improved process for the preparation of N-carboxyanhydrides by reaction of the corresponding amino acid or one of its salts with phosgene, diphosgene and/or triphosgene in a solvent medium, characterized in that at least a portion of the reaction is carried out under a pressure of less than 1000 mbar. The N-carboxyanhydrides are thus obtained with better yields and an improved purity.
Claims10
Process for the preparation of N-carboxyanhydrides by reaction of the corresponding α-, β- or γ-amino acid or one of its salts with phosgene, diphosgene and/or triphosgene in a solvent medium, characterized in that at least a portion of the reaction is carried out under a total pressure of less than 1000 mbar.
Dependencies are inferred from the claim text.