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US 6,603,011 B1Granted
3-pyridinyl compounds
AssigneeTargacept, Inc.
InventorsWilliam Scott Caldwell, Gary Maurice Dull, Grayland Page Dobson
Life of this patent
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Abstract
Patients susceptible to or suffering from central nervous system disorders are treated by administering effective amounts of aryl substituted aliphatic amine compounds, aryl substituted olefinic amine compounds or aryl substituted acetylenic amine compounds. A representative compound is (E)-N-methyl-5-(3-pyridinyl)-4-penten-2-amine.
Claims12
A compound having the formula:
- wherein X is selected from the group consisting of C—H, C—F, C—Cl , C—Br, C—I, C—NR′R″, C—CF3, C—CN, C—C2R′, C—SCH3, C—N3, C—SO2CH3, C—OR′, C—SR′, C—C(═O)NR′R″, C—NR′C(═O)R′, C—(C═O)R′, C—C(═O)OR′, C—CH2R′, C—OC(═O)R′, C—OC(═O)NR′R″ and C—NR′C(═O)OR′ where R′and R″ are individually hydrogen or C1-5 alkyl,
- n is 2, 3, 4, 5, 6, or 7,
- Z′ and Z″ individually represent hydrogen or C1-5 alkyl, at least one of Z′ or Z″ is C1-5 alkyl;
- A, A′ and A″ individually represent hydrogen or C1-5 alkyl or halo C1-5 alkyl;
- E′ and E″ individually represent H, C1-5 alkyl or halo C1-5 alkyl;
- and
- at least one E′ at the alpha position to the NZ′Z″ group represents C1-5 alkyl.
4 more elements
Dependencies are inferred from the claim text.