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US 6,603,006 B2Granted
Intermediate for the synthesis of amlodipine, a process for the preparation thereof and corresponding use
AssigneeEsteve Quimica, S.A.
InventorsLaura Coppi, Yolanda Gasanz Guillén, Julio Campón Pardo
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Abstract
An intermediate for the synthesis of amlodipine, a process for the preparation thereof and the corresponding use are disclosed. The intermediate is ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate and is of formula III: The process for the preparation thereof comprises reacting the acetoacetate of formula: with ammonium acetate; and the use thereof is for the preparation of the compound of formula: the process being conducted by reacting ethyl 3-amino-4-[2-(phthalimido)ethoxy]crotonate with a benzylidene derivative.
Claims1
A process for preparation for formula:
- comprising dissolving solid ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate of formula III:
- in an organic solvent, and reacting ethyl 3-amino-4-(2-(phthalimido)ethoxy)crotonate of formula III with a benzylidene derivative of formula VII:
Dependencies are inferred from the claim text.