Human elastase IV
AssigneeHuman Genome Sciences, Inc.
InventorsJohn M. Greene, Mark D. Adams
Life of this patent
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Abstract
Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial walls, improvement of serum lipid abnormality and improvement of serum lipoprotein metabolism are disclosed. Also disclosed are antagonist/inhibitors against such polypeptides and their use in treating inflammation, arthritis, e.g. rheumatoid arthritis and osteoarthritis, septic shock, pancreatitis and limiting tissue damage in ulceration. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
Claims16
An isolated protein consisting of at least 30 contiguous amino acid residues of SEQ ID NO:2.
An isolated protein consisting of at least 30 contiguous amino acid residues encoded by the cDNA in ATCC Deposit No. 75751.
Dependencies are inferred from the claim text.