Receptor structures
AssigneeBiovitrum AB
InventorsCharlotta Ljungqvist, Karin Nord, Per-Åke Nygren, Mathias Uhlén
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Abstract
The present invention relates to modified polypeptide derivatives of the B domain or Z domain of staphylococcal protein A (SPA). The derivatives contain amino acid substitutions that result in the ability of the B domain or Z domain to interact with at least one domain of a human Factor VIII protein, without substantially disrupting the structure and stability of the B domain or Z domain.
Claims16
A polypeptide comprising a derivative of the staphylococcal protein A (SPA) Z domain amino acid sequence of SEQ ID NO:1, wherein the derivative comprises between 4 and 20 substitutions of amino acid residues of the SPA Z domain, wherein at least the amino acid residues in positions 9, 10, 13 and 14 in SEQ ID NO:1 have been substituted by other amino acid residues, and wherein the derivative binds to at least one domain of a human Factor VIII protein.
Dependencies are inferred from the claim text.