Transdermal administration of phenylpropanolamine
AssigneeDermatrends, Inc.
InventorsTsung-Min Hsu, Russell Macy, Eric C. Luo
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Abstract
Methods and systems are provided for the transdermal administration of racemic phenylpropanolamine, i.e., a mixture of two or more of the four isomers of phenylpropanolamine, (+)-norephedrine, (−)-norephedrine, (+)-norpseudoephedrine, and (−)-norpseudoephedrine. Generally, the racemate will be a mixture of (+)-norephedrine and (−)-norephedrine. The racemic drug is administered along with a permeation enhancer. The permeation enhancer is preferably a basic compound, and optimally is a hydroxide-releasing agent such as sodium hydroxide.
Claims48
A method for treating an individual suffering from or susceptible to condition, disorder or disease that is responsive to administration of phenylpropanolamine, comprising administering a therapeutically effective amount of racemic phenylpropanolamine to a localized region of a human patient's body surface, in combination with an effective permeation-enhancing amount of a hydroxide-releasing agent selected from the group consisting of ammonium hydroxide, alkali metal hydroxides, alkaline earth metal hydroxides, magnesium oxide, calcium oxide, and mixtures thereof.
A device for the transdermal administration of racemic phenylpropanolamine, comprising:
- (a) at least one drug reservoir containing the racermic phenylpropanolamine and a hydroxide-releasing agent in an amount effective to enhance the flux of the drug through the body surface without causing damage thereto, wherein the hydroxide-releasing agent is selected from a group consisting of ammonium hydroxide, alkali metal hydroxides, alkaline earth metal hydroxides, magnesium oxide, calcium oxide, and mixtures thereof,
- (b) a means for maintaining the device in drug- and enhancer-transmitting relationship to the body surface;
- and
- (c) a backing layer that serves as the outer surface of the device during use.
Dependencies are inferred from the claim text.