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US 6,602,905 B1Granted
N-acyl homoserine lactones for the treatment of cardiac tachyarrhythmias, ischaemic heart disease or congestive heart failure
AssigneeThe University of Nottingham
InventorsSheila Margaret Gardiner, Terence Bennett, Barrie Walsham Bycroft, David Idris Pritchard, Paul Williams
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Abstract
Compounds having anti-fibrotic effects are provided. Also provided is a method for treating disorders, diseases or conditions associated with pathological fibrotic states. The compounds useful in the present invention are homocysteine thiolactone and selected derivatives thereof.
Claims8
A method for the treatment or prevention of cardiac tachyarrythmias, ischaemic heart disease or congestive heart failure in human and non-human mammals comprising administering an effective, non-toxic amount of a compound of the formula I:
- wherein n is 2 or 3;
- Y is O or NH;
- X is O or NH;
- and R is a 3-15C substituted aliphatic acyl group.
1 more element
Dependencies are inferred from the claim text.