Cyclopentane heptan(ENE)oic acid, 2-heteroarylalkenyl derivatives as therapeutic agents

A method of treating ocular hypertension which administering to a mammal having ocular hypertension a therapeutically-effective amount of a compound wherein said compound is represented by formula II:

• wherein the hatched segments represent a bonds, the solid triangle represents a b bond, wavy line attachments indicate either the alpha (a) or beta (b) configuration;
• R1 is hydrogen or a lower alkyl radical having up to six carbon atoms, X is selected from the group consisting of OR1, —N(R1)2, and —N(R5)SO2R6, wherein R5 represents hydrogen or CH2OR6 and R6 represents hydrogen or a lower alkyl radical having up to six carbon atoms and halogen substituted derivatives of said lower alkyl radical;
• Y is ═O or represents 2 hydrogen radicals, Z is selected from the group consisting of O and S, A is selected from the group consisting of N, —CH, and C, R2 is selected from the group consisting of hydrogen, halogen and lower alkyl having from 1 to 6 carbon atoms, R3 and R4 are selected from the group consisting of hydrogen, halogen, lower alkyl having from 1 to 6 atoms, or, together with,
• R3 and R4 forms a condensed aryl ring;
• provided however when A is selected from the group consisting of CH and C, R3 and R4 together with
• forms a condensed aryl ring.