Methods for nicotine replacement dosage determination
OwnerDavid P. L. Sachsinventor
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Abstract
A method for predicting nicotine replacement dosage to achieve a target nicotine serum concentration relies on measuring blood nicotine concentration prior to smoking cessation. At least two values corresponding to other patient characteristics, such as body mass, cumulative smoking, psychological dependence, age, and menopausal status, are also determined and used to predict expected blood nicotine concentrations based on nicotine replacement dosages. Such methods are useful in achieving target blood nicotine concentrations for smoking cessation and therapy.
Claims10
A method for determining a nicotine dosage necessary to achieve a target nicotine serum concentration in an individual patient who is ceasing smoking, said method comprising:
- (A) measuring a patient nicotine concentration while the patient is still smoking;
- and
- (B) determining the nicotine dosage as follows:
- (i) for male patients:
- determining the values of at least a body mass factor and a cumulative smoking factor;
- and
- determining the dosage to achieve the target nicotine serum concentration based on the patient's measured nicotine concentration, the body mass factor value, and the cumulative smoking factor value;
- or
- (ii) for female patients:
- determining at least the value of a psychological dependence factor and age;
- and
- determining the dosage to achieve the target nicotine serum concentration based on the patient's measured nicotine concentration, the psychological dependence factor value and the age.
Dependencies are inferred from the claim text.