Chronic, bolus administration of D-threo methylphenidate
AssigneeCelegene Corporation
InventorsMaghsoud M. Dariani, Andrew L. Zeitlin, Jerome B. Zeldis
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Abstract
Chronic bolus administration of D-threo methylphenidate is provided. The administration of the D-threo isomer eliminates adverse side effects associated with the DL racemate, and provides improved effectiveness. The compositions and methods of the invention are useful in treating nervous system disorders including attention deficit disorder, attention deficit hyperactivity disorder, and cognitive decline associated with systemic diseases such as acquired immunodeficiency syndrome.
Claims8
A method of treating at least one of attention deficit disorder, attention deficit hyperactivity disorder, or AIDS-related dementia, comprising the chronic administration of a compound having the formula:
- or a pharmaceutically acceptable salt thereof, wherein R1 is C1-C4 alkyl, and R2 is hydrogen or C1-C4 alkyl, substantially free of both l-threo and erythro forms thereof, said administration comprising a single, bolus dosage of said compound in each twenty-four hour period.
Dependencies are inferred from the claim text.