Acylquanidine derivatives, method for preparing same, application as medicines and pharmaceutical compositions containing them

A compound selected from the group consisting of a compound of the formula

• wherein R1 and R2 are independently hydrogen or alkyl of 1 to 6 carbon atoms unsubstituted or substituted by R3, or R1 and R2 together form a divalent alkylene of 2 to 9 carbon atoms, carbon atoms unsubstituted or substituted by R3, or R1 and R2 together form a divalent alkylene of 2 to 9 carbon atoms, saturated or unsaturated, unsubstituted or substituted by at least one member of the group consisting of halogen, (C1-C6)-alkyl, C1-C6)-alkoxy, (C6-C14)-aryl, (C6-C14)-aryl-(C1-C6)-alkyl, (C5-C14)-heteroaryl, (C5-C14)-heteroaryl-(C1-C6)-alkyl, (C3-C12)-cycloalkyl (C3-C12)-cycloalkyl-(C1-C6)-alkyl and oxo, said divalent alkylene being able to be attached at the level of the carbon-carbon bond to a carbocycle or a heterocycle with 5 to 7 members, containing 1 or 2 nitrogen atoms, saturated or unsaturated, unsubstituted or substituted by 1 or 2;
• R3 is selected from the group consisting of alkyl of 1 to 8 carbon atoms, alkoxy of 1 to 8 carbon atoms, aryl of 5 to 14 carbon atoms, arylalkyl of 5 to 14 carbon atoms and 1 to 4 alkyl carbon atoms, heteroaryl of 5 to 14 carbon atoms, halogen, CF3, —OH, —NO2, —NH alkyl of 1 to 4 carbon atoms, alkyl
• —NH—CO-alkyl and —CO-alkyl is a alkyl of 1 to 4 carbon atoms,
• R4 is selected from the group consisting of a) hydrogen, b) (C1-C6)-alkyl-CO—O—(C1-C4)-alkyl or (C1-C6)-alkyl group, unsubstituted or substituted by a member selected from the group consisting of hydroxyl, (C1-C4)-alkoxy, (C1-C4)-alkyl-SO2, NR9R9′ and N+R9R9′R9′X−, in which R9, R9′ and R9″ are independently selected from the group consisting of hydrogen, (C1-C6)-alkyl, (C5-C14)-aryl and (C5-C14)-aryl-C1-C6)-alkyl group and Q− is a physiologically acceptable anion,
• the dotted lines representing the position of the bond;
• R5 is selected from the group consisting of —COR6, —CO2R6, —SO2R6, —SO2NHR6, —SO2NHCOR6, —SO2NHCO2R6, CONH2 and —CONHR6 in which R6 is selected from the group consisting of (C1-C8)-alkyl, (C6-C14)-aryl,
• (C6-C14)-aryl-(C1-C6)-alkyl, (C5-C14)-heteroaryl, (C5-C14)-heteroaryl-C1-C6)-alkyl,
• (C3-C20)-(mono-, Bi or tri)-cycloalkyl-(C1-C6)-alkyl, the aryl or heteroaryl being unsubstituted or substituted by 1, to 3, R3;
• R7 is selected from the group consisting of hydrogen, (C1-C6)-alkyl-O—CO—, hydroxyl, (C1-C6)-alkyl-O—CO—O and nitro;
• R8 is selected from the group consisting of hydrogen atom, halogen and alkoxy of 1 to 6 carbon atoms;
• m is equal to 0, 1, 2 or 3;
• n is an integer equal to 1, 2 or 3;
• said compounds of formula (I) being in optical isomeric, enantiomeric and diasteriomeric form, alone or in a mixture in any ratio, the acylguanidine group adjacent to the phenyl being in para or meta position to the oxygen, or its pharmaceutically acceptable salts.