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US 6,602,868 B2Granted
Treatments for restless legs syndrome
AssigneePharmacia & Upjohn Company
InventorsSylvia McBrinn, Richard Wayne Anderson
Life of this patent
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Abstract
The invention provides methods and use of heterocyclic amines, and phenylazacycloalkane compounds, and their pharmacologically acceptable salts for the treatment of Restless Legs Syndrome (RLS).
Claims13
A method for treating restless legs syndrome (RLS) in a patient suffering from RLS, comprising the administration of an effective amount of a compound of formula I
- or a pharmaceutically acceptable salt thereof, wherein:
- R1, R2, and R3 are independently
- a) hydrogen,
- b) C1-6 alkyl, C3-5 alkenyl, or C3-5 alkynyl,
- c) C3-7 cycloalkyl, C4-10 cycloalkyl- or phenyl-substituted C1-6 alkyl, or
- d) R1 and R2 are joined to form a C3-7 cyclic amine which can contain additional heteroatoms and/or unsaturation;
- X is
- a) hydrogen,
- b) C1-6 alkyl
- c) halogen,
- d) hydroxy,
- e) alkoxy,
- f) cyano,
- g) carboxamide,
- h) carboxyl, or
- i) carboalkoxyl;
- A is
- a) CH, CH2, CH-halogen, CHCH3, C═O, C═S, C—SCH3, C═NH, C—NH2, C—NHCH3, C—NHCOOCH3, or C—NHCN;
- b) SO2, or
- c) N;
- B is
- a) CH2, CH, CH-halogen, or C═O, or
- b) N, NH or N—CH3;
- c) O
- n is 0 or 1;
- and
- D is
- a) CH, CH2, CH-halogen or C═O,
- b) O,
- c) N, NH or N—CH3.
27 more elements
Dependencies are inferred from the claim text.