Antagonists of alpha-melanocyte stimulating hormone and methods based thereon
OwnerJ. Mark Quillan, Channa K. Jayawickreme +1inventors
InventorsJ. Mark Quillan, Channa K. Jayawickreme, Michael R. Lerner
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Abstract
Peptide antagonists of α-melanocyte stimulating hormone are disclosed, together with methods of inhibiting the effects of α-melanocyte stimulating hormone on cells or tissues sensitive to that hormone. In particular, methods for lightening the pigmentation of skin and for treating malignant melanoma, as well as kits for practicing the invention are also disclosed.
Claims10
A peptide antagonist of α-melanocyte stimulating hormone comprising the amino acid sequence D-Trp-Arg-Leu or D-Trp-Arg-Leu-NH2.
A peptide antagonist of α-melanocyte stimulating hormone, that is D-Trp-Arg-Leu or D-Trp-Arg-Leu-NH2.
A pharmaceutical composition comprising (a) a peptide, said peptide comprising the amino acid sequence D-Trp-Arg-Leu or D-Trp-Arg-Leu-NH2, and (b) a pharmaceutically acceptable carrier.
A pharmaceutical composition comprising (a) a tripeptide, said tripeptide being D-Trp-Arg-Leu or D-Trp-Arg-Leu-NH2, and (b) a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.