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US 6,602,524 B2Granted
Microspheres for use in the treatment of cancer
AssigneeUniversity of Florida
InventorsChristopher D. Batich, Adam Leckey, J. Nicolas Vauthey
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AssigneeUniversity of Florida
InventorsChristopher D. Batich, Adam Leckey, J. Nicolas Vauthey
Estimating the term…
The subject invention pertains to novel materials and methods for use in treating patients afflicted with oncological disorders, such as tumors. One aspect of the invention concerns methods for treating tumors comprising the administration of drug loaded pH-sensitive microspheres to a patient in need of anticancer therapy. The pH-sensitive microspheres have a swelling transition with the pH range found in or near tumor tissue. When the microspheres swell, the loaded drug is released into the microenvironment of the tumor tissue. The subject invention also pertains to novel microspheres useful in the methods of the invention. The microspheres are capable of effectively releasing a loaded substance at a pre-determined pH. The subject invention also concerns novel methods for synthesizing the microspheres of the present invention.
A method of treating a patient having a tumor, said method comprising administering to the patient an effective amount of pH-sensitive microspheres, wherein said microspheres comprise a cross-linked polymer gel comprising ethyl methacrylate, diethyl aminoethyl methacrylate, and divinyl benzene, wherein said microspheres contain a substance selected from the group consisting of cytotoxic agents, chemotherapeutic agents, and radionuclides, and wherein said microspheres are capable of releasing said substance at a pH range associated with the tumor microenvironment, over a period of days.
A method of treating a tumor comprising administering pH-sensitive microspheres in a blood vessel suitable for carrying said microspheres to said tumor, wherein said microspheres comprise a cross-linked polymer gel comprising ethyl methacrylate, diethyl aminoethyl methacrylate, and divinyl benzene, wherein said microspheres contain a substance selected from the group consisting of cytotoxic agents, chemotherapeutic agents, and radionuclides, and wherein said microspheres are capable of releasing said substance at a pre-determined pH, over a period of days.
A pH-sensitive microsphere comprising a cross-linked polymer gel comprising ethyl methacrylate, diethyl aminoethyl methacrylate, and divinyl benzene, wherein said pH-sensitive microsphere is loaded with a substance selected from the group consisting of cytotoxic agents, chemotherapeutic agents, and radionuclides, and wherein said pH-sensitive microsphere is capable of effectively releasing said substance at a predetermined pH, over a period of days.
A composition comprising a plurality of monodisperse pH-sensitive microspheres, wherein said pH-sensitive microspheres comprise a cross-linked polymer gel comprising ethyl methacrylate, diethyl aminoethyl methacrylate, and divinyl benzene, wherein said pH-sensitive microspheres are loaded with a substance selected from the group consisting of cytotoxic agents, chemotherapeutic agents, and radionuclides, and wherein said pH-sensitive microspheres are capable of effectively releasing said substance at a predetermined pH, over a period of days.
Dependencies are inferred from the claim text.